Endocrine Abstracts

Introduction: Disease-related malnutrition (DRM) is characterized by the presence of an acute or chronic inflammatory response. The traditional parameters for diagnosis, such as albumin, have failed in their application, forcing a reconsideration of the criteria used for the diagnosis of DRM. The ratio of C-Reactive Protein to prealbumin (CP ratio) allows to assess nutritional changes in relation to the inflammatory environment. The objective of this study is to assess the dia...

This study examined the mechanism by which genistein produced adverse effects in pregnant laboratory rats. Pregnant rats were divided into control (Con) and genistein (Gen) force fed (2 mg/kg) groups. At terminal gestation day (GD) ranging from 0 to 20, the rats were sacrificed, and blood samples and amniotic fluids were collected. Thyroid hormone, C-reactive protein (CRP) and leptin assay was carried using the blood samples. Leptin was also assayed in the placenta and amnioti...

Objective: To investigate the metabolic syndrome and dyslipidemia prevalence among human immunodeficiency virus (HIV) and hepatitis C (HCV) subjects in Southern Brazil.Methods: Cross-sectional study, including 127 subjects (n=59 HIV positive only, n=36 HIV/HCV positive, and n=32 HCV positive only) were accessed for HOMA index, metabolic syndrome, and dyslipidaemias.Results: In HIV group there were 27% met...

Prediction of amputation would aid clinicians in the management of the diabetic foot infections. We aimed to assess the predictability of baseline and early post-treatment levels of acute phase reactants on the outcome of patients with diabetic foot infections.In this study, we included patients with infected diabetic foot ulcers who were hospitalized in Dokuz Eylul University Hospital between January 2003 and January 2008, of which data were collected p...

Objective: We retrospectively analyzed patients with type 1 diabetes onset, attended during the years 2005 and 2006 on the specific query of type 1 DM debut of a tertiary hospital, with initial treatment assessment, at 1 and 5 years evolution.Results: Patients were treated for newly diagnosed DM 1, 25 patients (72% male, 28% female) mean age 23.2 years (14–36), mean BMI: 23.18 (18–33.8%).The clinical presentation included: 88.24% presented with...

Background and aim: C-reactive protein (CRP) is a sensitive marker for systemic inflammation. In this study we aimed to investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and BMI, body fat mass and fat distribution in healthy subjects.Subjects and methods: A total 117 healthy subjects aged with 20–68 yr [normal weight (BMI 18.5–25.0 kg/m2, n:35), overweight (BMI: 25–30 kg/m2</sup...

Background: Familial Hyperinsulinaemic hypoglycaemia (FHH) is a very rare disease with heterogeneous clinical manifestation causing risk of late diagnosis or even misdiagnosis. In infants and children, it can lead to serious and permanent damage to the central nervous system. FHH has been correlated with mono-gene mutations in approximately 48% of cases. Clinical manifestation may vary even in the same affected GCK mutation family.Objective: To describe ...

Introduction: Extreme insulin resistance monogenic syndromes, including type A insulin resistance syndrome and congenital lipodystrophies, share some phenotypic characteristics with polycystic ovary syndrome (PCOS). These conditions have an increased risk for developing cardiovascular disease and diabetes mellitus. Thus, both an early diagnosis and a personalized management are required at clinical realm.Objective: To assess the prevalence of mutations i...

Introduction: Pancreatic neuroendocrine tumors (panNETs) are often inoperable at diagnosis. The mTORC1 inhibitor everolimus is approved for the treatment of advanced NETs. Unfortunately, the development of resistance against everolimus limits its clinical efficacy.Aim: Our aim was to establish an everolimus-resistant panNET cell line to find common mechanisms of resistance.Methods: Pancreatic neuroendocrine tumor cells (BON1) were ...

Introduction: In patients with β thalassemia major (TM) The interplay between liver siderosis and hepatitis C virus (HCV) infection may facilitates the progression to insulin resistance (IR) and diabetes mellitus (DM).Objectives: Many TM patients are infected with either HCV. Therefore, we aimed to explore if there is any association between DM and HCV-RNA positivity with different genotypes.Patients and methods: 148 TM patien...